Part1:The reason why Huperzine a Huperzia Serrata is called "gold in plants".
Huperzine A Huperzia Serrata is a chemical that helps improve memory and treat Alzheimer's, a natural plant alkaloid; Huperzine-A is derived from the bryophyte Huperzine serpentis commonly found in low-lying areas of Asia Huperzia serrata (Tnunb) Trey., also known as Melaleuca tower, is often used to treat myasthenia gravis, bruises and other diseases. In the early 1980s, Chinese medical researchers isolated Huperzine A with strong biological activity, which is a natural, efficient and reversible second-generation acetylcholinesterase (AChE) inhibitor. Alzheimer's disease has a significant effect. Huperzine A has a high therapeutic index, a long action time, and no toxic and side effects, but its content is very low in natural whole herbs. Many people in China use separation methods such as high performance liquid chromatography and silica gel column chromatography. Although the yield is high, the productivity is very low and the production cost is high. Therefore, Huperzine a Huperzia Serrata is also called "gold in plants".
Part2：The source of extraction of Huperzine a Huperzia Serrata
Natural "Huperzine A" (Huperzine A, Hup A) is a hemiterpene alkaloid derived from the fern Huperzia serrata. It is a highly efficient, highly selective and reversible acetylcholinesterase (AchE) inhibitor. It is a promising drug for the treatment of "Alzheimer's disease" (AD). Hup A was higher in the stems and leaves and lower in the roots. Huperus serpentis is widely distributed around the world, with a total of 400 different species. Among them, Huperus serpentis grown in Australia, Hawaii, mainland China, etc., is widely used. The study found that the Hup A quality score did not change much in different seasons. The research also proved that Huperzine A has the potential of neuroprotection and prevention of chemical weapons, which has aroused extensive attention and research by scholars from all over the world.
Part3:Medicinal efficacy and mechanism of action of Huperzine a Huperzia Serrata
Huperzine A is suitable for benign memory impairment to significantly improve cognitive function, behavior and mood disorders in AD patients. Huperzine A also improves memory impairment caused by dementia patients and organic cerebral diseases. The water decoction of Masseus chinensis from Huperaceae has good anti-cholinesterase effect on mice.
Pharmacological experiments show that:
One of the major chemical functions of Huperzine A is its use as an acetylcholinesterase inhibitor. Acetylcholinesterase is an enzyme in the brain that breaks down the neurotransmitter acetylcholine, which is responsible for the synaptic function of numerous neurons and neural excitation in the central nervous system. A single molecule of acetylcholinesterase can reduce the function of about 25,000 acetylcholine molecules. Inhibitors of this enzyme are often used to make nerve gas preparations, because too much acetylcholine in the body can cause muscle paralysis and death by suffocation.
Alzheimer's patients are often deficient in acetylcholine and depressed cognitive function, because acetylcholine plays an important role in nerve stimulation, memory and learning, and excitation. Lowering acetylcholinesterase levels releases acetylcholine, allowing more neurons to fire.
In addition to being used to treat Alzheimer's disease, Huperzine A can also be used to treat myasthenia gravis, and has the effects of analgesia and improvement of learning and memory functions. Specific effects include:
1. Huperzine A has the most selective inhibitory effect on acetylchoesterase.
2. Huperzine A has a significant inhibitory effect on the activity of acetylcholinesterase in the cerebral cortex, hippocampus, septum, medulla oblongata, cerebellum and hypothalamus. This inhibitory effect is in a dose-dependent manner, with good oral bioavailability, and Easily penetrates the blood-brain barrier.
3. Huperzine A helps to repair short-term memory damage and long-term brain power, reducing the degree of annoying aging.
4. Huperzine A is a reversible acetylcholinesterase inhibitor.
